Ontology highlight
ABSTRACT:
SUBMITTER: Xu F
PROVIDER: S-EPMC7399484 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Xu Funeng F Li Xilin X Huang Xuehui X Pan Jingmei J Wang Yi Y Zhou Shaobing S
Science advances 20200731 31
Autophagy is involved in the occurrence and development of tumors. Here, a pH-responsive polymersome codelivering hydroxychloroquine (HCQ) and tunicamycin (Tuni) drugs is developed to simultaneously induce endoplasmic reticulum (ER) stress and autophagic flux blockade for achieving an antitumor effect and inhibiting tumor metastasis. The pH response of poly(β-amino ester) and HCQ synergistically deacidifies the lysosomes, thereby blocking the fusion of autophagosomes and lysosomes and lastly blo ...[more]