High S phase kinase-associated protein 2 expression is a potential prognostic biomarker for glioma.

ABSTRACT: S phase kinase-associated protein 2 (SKP2), a substrate recognizing protein, serves an important role in promoting cell cycle progression through ubiquitination and degradation of cell cycle inhibitors. In the present study, the clinical significance of SKP2 in gliomas was studied; 395 glioma specimens and 20 non-neoplastic tissues were collected and immunohistochemical analysis was performed. χ² test was used to assess the associations between SKP2 expression and clinical parameters. Overall survival (OS) curves were plotted according to the Kaplan-Meier method. In the tested glioma samples, SKP2 expression was mainly observed in glioblastomas (GBMs). Survival analysis demonstrated that the overall survival time of the high SKP2 expression group was lower compared with the low

SUBMITTER: Cheng ZJ 

PROVIDER: S-EPMC7400960 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature