Distinct prognostic values and antitumor effects of tumor growth factor ?1 and its receptors in gastric cancer.

ABSTRACT: Gastric cancer (GC) is one of the most common malignancies and is the second leading cause of cancer-associated mortality world-wide. In the present study, the prognostic value and antitumor effects of transforming growth factor ?1 (TGF?1) and its receptors in GC were explored. The online Kaplan-Meier plotter database was used to investigate the prognostic values of TGF?1 and its receptors. The present study demonstrated that low mRNA expression levels of TGF?1 and its 3 receptors, transforming growth factor ?1 (TGF?R1), TGF?R2 and TGF?R3, was associated with improved overall survival time in patients with GC. Cell Counting Kit-8 and Transwell assays were used to confirm the effects of TGF?1, TGF?R1, TGF?R2 and TGF?R3 on the proliferation, migration and invasiveness of the AGS and MKN45 GC cell lines. It was found that the knockdown of these genes blocked cell proliferation, migration and invasion in GC cells. To the best of our knowledge, the present study is the first to determine the role of TGF?R1 and TGF?R3 in GC cells. The results indicate that in addition to TGF?1 and TGF?R2, TGF?R1 also plays a specific role in the occurrence and development of tumors. Thus, these markers may be considered as potential prognostic indicators in human GC. The findings of the present study indicate that not only TGF?1 and TGF?R2, but also TGF?R1 is involved in the progression of GC. The findings of the present study provide new ideas and approaches for the treatment of patients with GC.

SUBMITTER: Liu F 

PROVIDER: S-EPMC7400994 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature