Ontology highlight
ABSTRACT:
SUBMITTER: Balbach M
PROVIDER: S-EPMC7401349 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Biology of reproduction 20200801 2
Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third assumption and propose that despite its wide expression, soluble adenylyl cyclase (sAC: ADCY10), which is essential for male fertility, is a valid target. We hypothesize that an acute-acting sAC inhi ...[more]