Ontology highlight
ABSTRACT:
SUBMITTER: Bauchmuller K
PROVIDER: S-EPMC7401439 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Bauchmuller Kris K Manson Jessica J JJ Tattersall Rachel R Brown Michael M McNamara Christopher C Singer Mervyn M Brett Stephen J SJ
Journal of the Intensive Care Society 20200107 3
Haemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune dysregulation, characterised by extreme inflammation, fever, cytopaenias and organ dysfunction. HLH can be triggered by conditions such as infection, autoimmune disease and malignancy, among others. Both a familial and a secondary form have been described, the latter being increasingly recognised in adult patients with critical illness. HLH is difficult to diagnose, often under-recognised and carries a high mortality. Patie ...[more]