Ontology highlight
ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC7401806 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chen Keyu K Yang Rui R Li Yubing Y Zhou Jin Chuan JC Zhang Mingjie M
The Journal of cell biology 20200801 8
Giant ankyrin-B (gAnkB) is a 440-kD neurospecific ankyrin-B isoform and a high-confidence target for autism mutations. gAnkB suppresses axon branching through coordination of cortical microtubules, and autism-related mutation of gAnkB results in ectopic neuronal connectivity. We identified a bipartite motif from gAnkB, which bundles and avidly binds to microtubules in vitro. This motif is composed of a module of 15 tandem repeats followed by a short, conserved fragment also found in giant ankyri ...[more]