Ontology highlight
ABSTRACT:
SUBMITTER: Griffin JD
PROVIDER: S-EPMC7402190 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Griffin J Daniel JD Leon Martin A MA Salash Jean R JR Shao Michael M Hartwell Brittany L BL Pickens Chad J CJ Sestak Joshua O JO Berkland Cory C
Biomacromolecules 20190502 5
Antigen valency plays a fundamental role in directing the nature of an immune response to be stimulatory or tolerogenic. Soluble antigen arrays (SAgAs) are an antigen-specific immunotherapy that combats autoimmunity through the multivalent display of autoantigen. Although mechanistic studies have shown SAgAs to induce T- and B-cell anergy, the effect of SAgA valency has never been experimentally tested. Here, SAgAs of discrete antigen valencies were synthesized by click chemistry and evaluated f ...[more]