Ontology highlight
ABSTRACT:
SUBMITTER: Muto T
PROVIDER: S-EPMC7402480 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Muto Tomoya T Walker Callum S CS Choi Kwangmin K Hueneman Kathleen K Smith Molly A MA Gul Zartash Z Garcia-Manero Guillermo G Ma Averil A Zheng Yi Y Starczynowski Daniel T DT
Nature immunology 20200420 5
Despite evidence of chronic inflammation in myelodysplastic syndrome (MDS) and cell-intrinsic dysregulation of Toll-like receptor (TLR) signaling in MDS hematopoietic stem and progenitor cells (HSPCs), the mechanisms responsible for the competitive advantage of MDS HSPCs in an inflammatory milieu over normal HSPCs remain poorly defined. Here, we found that chronic inflammation was a determinant for the competitive advantage of MDS HSPCs and for disease progression. The cell-intrinsic response of ...[more]