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Anosmia in the course of COVID-19: A case report.

ABSTRACT: RATIONALE:A sudden onset of anosmia has been recently recognized as a symptom of coronavirus disease (COVID-19). PATIENT CONCERNS:Here, we describe a case of complete anosmia in a young male with COVID-19. Although he had fever and odynophagia, no abnormalities were observed in his nasopharyngeal mucosa, suggesting that his anosmia resulted from olfactory neuropathy. DIAGNOSES:COVID-19 was confirmed by RNA detection in nasopharyngeal swab specimen. INTERVENTIONS:The patient received olfactory training and B complex vitamins. OUTCOMES:On day 30, the patient reported complete recovery of his sense of smell. LESSONS:As early diagnosis is fundamental to control the spread of COVID-19 infection, we emphasize that anosmia identified in febrile cases during the COVID-19 epidemic may be a symptom indicative of the disease. Moreover, COVID-19-related anosmia can be completely reversible.

SUBMITTER: Pissurno NSCA

PROVIDER: S-EPMC7402711 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Anosmia in the course of COVID-19: A case report.

Pissurno Neisa Santos Carvalho Alves NSCA Lichs Gislene Garcia de Castro GGC Santos Evelyn Jaqueline Lima Dos EJLD Druzian Angelita Fernandes AF Oliveira Sandra Maria do Valle Leone de SMDVL Paniago Anamaria Mello Miranda AMM

Medicine 20200701 31

<h4>Rationale</h4>A sudden onset of anosmia has been recently recognized as a symptom of coronavirus disease (COVID-19).<h4>Patient concerns</h4>Here, we describe a case of complete anosmia in a young male with COVID-19. Although he had fever and odynophagia, no abnormalities were observed in his nasopharyngeal mucosa, suggesting that his anosmia resulted from olfactory neuropathy.<h4>Diagnoses</h4>COVID-19 was confirmed by RNA detection in nasopharyngeal swab specimen.<h4>Interventions</h4>The ...[more]

PMID: 32756107

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Project description:Background: This systematic review had three aims: i) to determine the frequency of anosmia (or other smell disorders) and dysgeusia (or other taste disorders) in COVID-19 patients; ii) to determine whether anosmia or dysgeusia are independently associated with COVID-19 diagnosis; and iii) to determine whether anosmia or dysgeusia are prognostic factors for impaired outcomes among COVID-19 patients. Methods: On April 20 th, 2020, we search MEDLINE, Embase, Global Health, Scopus, Web of Science and MedXriv. We used terms related to COVID-19, smell and taste disorders. We selected case series, cross-sectional, case-control and cohort studies. We included studies with COVID-19 patients describing their symptoms; studies that compared smell and taste disorders between COVID-19 patients and otherwise healthy subjects; and studies comparing smell and taste disorders between COVID-19 severe and mild/moderate cases. Because of methodological heterogeneity and the limited number of results, a qualitative synthesis is presented. Results: From 31 reports, we selected six (n=2,757). Six studies reported the proportion of smell and taste disorders among COVID-19 patients. Two reports studied whether smell and taste disorders were independently associated with COVID-19 diagnosis. No reports studied the association with impaired outcomes among COVID-19 patients. The frequency of anosmia ranged between 22%-68%. The definition of taste disorders varied greatly, with dysgeusia present in 33% and ageusia in 20%. People who reported loss of smell and taste had six-fold higher odds of being COVID-19 positive; similarly, anosmia and ageusia were associated with 10-fold higher odds of COVID-19 diagnosis. Conclusions: The frequency of smell and taste disorders is as high as other symptoms, thus, at least anosmia for which the definition was more consistent, could be included in lists of COVID-19 symptoms. Although there is promising evidence, it is premature to conclude that smell and taste disorders are strongly associated with COVID-19 diagnosis. Registration: PROSPERO CRD42020181308.

Dataset Information

Anosmia in the course of COVID-19: A case report.

Publications

Anosmia in the course of COVID-19: A case report.

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