Comparative Safety and Effectiveness of Direct-Acting Oral Anticoagulants Versus Warfarin: a National Cohort Study of Nursing Home Residents.

ABSTRACT:

Background

Research comparing direct-acting oral anticoagulants (DOACs) to warfarin has excluded nursing home residents, a vulnerable and high-risk population.

Objective

To compare the safety and effectiveness of DOACs versus warfarin.

Design

New-user cohort study (2011-2016).

Patients

US nursing home residents aged > 65 years with non-valvular atrial fibrillation enrolled in fee-for-service Medicare for > 6 months.

Exposures

Initiators of DOACs (2881 apixaban, 1289 dabigatran, 3735 rivaroxaban) were 1:1 propensity matched to warfarin initiators.

Main measures

Outcomes included ischemic stroke or transient ischemic attack (i.e., ischemic cerebrovascular event), bleeding (extracranial or intracranial), other vascular events, death, and a composite

SUBMITTER: Alcusky M 

PROVIDER: S-EPMC7403286 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature