MiR-4634 augments the anti-tumor effects of RAD001 and associates well with clinical prognosis of non-small cell lung cancer.
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ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC7403585 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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miR-4634 augments the anti-tumor effects of RAD001 and associates well with clinical prognosis of non-small cell lung cancer.
Liu Sile S Zang Hongjing H Zheng Hongmei H Wang Weiyuan W Wen Qiuyuan Q Zhan Yuting Y Yang Yang Y Ning Yue Y Wang Haihua H Fan Songqing S
Scientific reports 20200804 1
MicroRNA (miRNA) is involved in the physiological and pathological processes of various malignancies. In this study, miRNA microarray analysis showed that miR-4634 levels in A549 cells increased significantly after everolimus (RAD001) treatment. Decreased expression of miR-4634 was also found in non-small-cell lung carcinoma (NSCLC) cell lines and patients' tumors by qPCR. Additionally, a combination of miR-4634 and RAD001 exerted synergistic antitumor efficacy by inhibiting cell proliferation, ...[more]
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