Ontology highlight
ABSTRACT:
SUBMITTER: Han H
PROVIDER: S-EPMC7403662 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Han Hailong H Tan Jieqiong J Wang Ruoxi R Wan Huida H He Yaohui Y Yan Xinxiang X Guo Jifeng J Gao Qingtao Q Li Jie J Shang Shuai S Chen Fang F Tian Runyi R Liu Wen W Liao Lujian L Tang Beisha B Zhang Zhuohua Z
EMBO reports 20200602 8
Impairment of PINK1/parkin-mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that PINK1 directly phosphorylates Drp1 on S616. Drp1<sup>S616</sup> phosphorylation is significantly reduced in cells and mouse tissues deficient for PINK1, but unaffected by parkin inactivation. PINK1-mediated mitochondrial fission is Drp1<sup>S616</sup> phosphorylation dependent. Overexpression of either wild-type Drp1 or o ...[more]