Ontology highlight
ABSTRACT:
SUBMITTER: Akhtar S
PROVIDER: S-EPMC7403981 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20200715 14
Multiple myeloma (MM) is a hematologic disorder of B lymphocytes characterized by the accumulation of malignant plasma cells (PCs) in the bone marrow. The altered plasma cells overproduce abnormal monoclonal immunoglobulins and also stimulate osteoclasts. The host's immune system and microenvironment are of paramount importance in the growth of PCs and, thus, in the pathogenesis of the disease. The interaction of MM cells with the bone marrow (BM) microenvironment through soluble factors and cel ...[more]