Ontology highlight
ABSTRACT:
SUBMITTER: Gyvyte U
PROVIDER: S-EPMC7404198 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Gyvyte Ugne U Lukosevicius Rokas R Inciuraite Ruta R Streleckiene Greta G Gudoityte Greta G Gudoityte Greta G Bekampyte Justina J Valentini Serena S Salteniene Violeta V Ruzgys Paulius P Satkauskas Saulius S Zviniene Kristina K Kupcinskas Juozas J Skieceviciene Jurgita J
International journal of molecular sciences 20200721 14
Deregulated microRNA (miRNA) expression profiles and their contribution to carcinogenesis have been observed in virtually all types of human cancer. However, their role in the pathogenesis of rare mesenchymal gastrointestinal stromal tumors (GISTs) is not well defined, yet. In this study, we aimed to investigate the role of two miRNAs strongly downregulated in GIST-miR-375-3p and miR-200b-3p-in the pathogenesis of GIST. To achieve this, miRNA mimics were transfected into GIST-T1 cells and change ...[more]