Dataset Information

The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan.

ABSTRACT:

Background

The outbreak of coronavirus disease 2019 (COVID-19) is a critical challenge for public health. The effect of COVID-19 on liver injury has not been fully established.

Aims

To evaluate the dynamic changes in liver function and the relationship between liver damage and prognosis in patients with COVID-19.

Methods

Retrospective analysis of clinical data of 675 patients with COVID-19 in Zhongnan Hospital of Wuhan University from January 3 to March 8, 2020. Patients were classified as having normal or abnormal liver function and liver injury.

Results

Of 675 patients, 253 (37.5%) had abnormal liver function during hospitalisation, and 52 (7.7%) had liver injury. The dynamic changes of ALT and AST levels were more significant in patients with liver injury and in those who died. AST >3-fold upper limit of normal (ULN) had the highest risk of death and mechanical ventilation. Compared to patients with normal AST levels, mortality and risk of mechanical ventilation significantly increased 19.27-fold (95% confidence interval [CI], 4.89-75.97; P < 0.0001) and 116.72-fold (95% CI, 31.58-431.46; P < 0.0001), respectively, in patients with AST above 3-fold ULN. Increased leucocytes, decreased lymphocytes and female sex were independently associated with liver injury.

Conclusions

The dynamic changes in liver function may have a significant correlation with the severity and prognosis of COVID-19. Increased index of liver injury was closely related to mortality and need for mechanical ventilation. Therefore, these indicators should be closely monitored during hospitalisation.

SUBMITTER: Huang H

PROVIDER: S-EPMC7404742 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan.

Huang Haijun H Chen Shanshan S Li Hong H Zhou Xian-Long XL Dai Yining Y Wu Jia J Zhang Jun J Shao Lina L Yan Rong R Wang Mingshan M Wang Jiafeng J Tu Yuexing Y Ge Minghua M

Alimentary pharmacology & therapeutics 20200722 6

<h4>Background</h4>The outbreak of coronavirus disease 2019 (COVID-19) is a critical challenge for public health. The effect of COVID-19 on liver injury has not been fully established.<h4>Aims</h4>To evaluate the dynamic changes in liver function and the relationship between liver damage and prognosis in patients with COVID-19.<h4>Methods</h4>Retrospective analysis of clinical data of 675 patients with COVID-19 in Zhongnan Hospital of Wuhan University from January 3 to March 8, 2020. Patients we ...[more]

PMID: 32697870

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Dataset Information

The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan.

Background

Aims

Methods

Results

Conclusions

Publications

The association between markers of liver injury and clinical outcomes in patients with COVID-19 in Wuhan.

Similar Datasets

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