The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity.
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ABSTRACT:
SUBMITTER: Ovsyannikova IG
PROVIDER: S-EPMC7404857 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity.
Ovsyannikova Inna G IG Haralambieva Iana H IH Crooke Stephen N SN Poland Gregory A GA Kennedy Richard B RB
Immunological reviews 20200713 1
This article provides a review of studies evaluating the role of host (and viral) genetics (including variation in HLA genes) in the immune response to coronaviruses, as well as the clinical outcome of coronavirus-mediated disease. The initial sections focus on seasonal coronaviruses, SARS-CoV, and MERS-CoV. We then examine the state of the knowledge regarding genetic polymorphisms and SARS-CoV-2 and COVID-19. The article concludes by discussing research areas with current knowledge gaps and pro ...[more]
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