Ontology highlight
ABSTRACT:
SUBMITTER: Joyner JA
PROVIDER: S-EPMC7404987 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Joyner Jason A JA Daly Seth M SM Peabody Julianne J Triplett Kathleen D KD Pokhrel Srijana S Elmore Bradley O BO Adebanjo Diane D Peabody David S DS Chackerian Bryce B Hall Pamela R PR
Toxins 20200711 7
The pore-forming cytotoxin α-hemolysin, or Hla, is a critical <i>Staphylococcus aureus</i> virulence factor that promotes infection by causing tissue damage, excessive inflammation, and lysis of both innate and adaptive immune cells, among other cellular targets. In this study, we asked whether a virus-like particle (VLP)-based vaccine targeting Hla could attenuate <i>S. aureus</i> Hla-mediated pathogenesis. VLPs are versatile vaccine platforms that can be used to display target antigens in a mu ...[more]