Ontology highlight
ABSTRACT:
SUBMITTER: Hernando-Amado S
PROVIDER: S-EPMC7406369 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Hernando-Amado Sara S Sanz-García Fernando F Martínez José Luis JL
Science advances 20200805 32
The analysis of trade-offs, as collateral sensitivity, associated with the acquisition of antibiotic resistance, is mainly based on the use of model strains. However, the possibility of exploiting these trade-offs for fighting already resistant isolates has not been addressed in depth, despite the fact that bacterial pathogens are frequently antibiotic-resistant, forming either homogeneous or heterogeneous populations. Using a set of <i>Pseudomonas aeruginosa</i>-resistant mutants, we found that ...[more]