Ontology highlight
ABSTRACT:
SUBMITTER: Stasiak SE
PROVIDER: S-EPMC7406377 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Stasiak S E SE Jamieson R R RR Bouffard J J Cram E J EJ Parameswaran H H
Science advances 20200805 32
In this study, we report the existence of a communication system among human smooth muscle cells that uses mechanical forces to frequency modulate long-range calcium waves. An important consequence of this mechanical signaling is that changes in stiffness of the underlying extracellular matrix can interfere with the frequency modulation of Ca<sup>2+</sup> waves, causing smooth muscle cells from healthy human donors to falsely perceive a much higher agonist dose than they actually received. This ...[more]