Ontology highlight
ABSTRACT:
SUBMITTER: Han S
PROVIDER: S-EPMC7406436 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zhongguo fei ai za zhi = Chinese journal of lung cancer 20200701 7
Mesenchymal-epithelial transition factor (MET) gene is an important tumor driver gene of non-small cell lung cancer (NSCLC). Drugs targeting MET 14 exon skipping mutation bring new hope to patients. MET inhibitors that are currently on the market or are about to be marketed include: crizotinib, cabozantinib, savolitinib and tepotinib. The objective response rate of MET inhibitors is high, and the safety is good. However, resistance of MET-tyrosine kinase inhibitor (TKI) is inevitable, so it is n ...[more]