Dataset Information

Acquisition Duration in Resting-State Arterial Spin Labeling. How Long Is Enough?

ABSTRACT: Resting-state Arterial Spin Labeling (rs-ASL) is a rather confidential method compared to resting-state BOLD. As ASL allows to quantify the cerebral blood flow, unlike BOLD, rs-ASL can lead to significant clinical subject-scaled applications. Despite directly impacting clinical practicability and functional networks estimation, there is no standard for rs-ASL regarding the acquisition duration. Our work here focuses on assessing the feasibility of ASL as an rs-fMRI method and on studying the effect of the acquisition duration on the estimation of functional networks. To this end, we acquired a long 24 min 30 s rs-ASL sequence and investigated how estimations of six typical functional brain networks evolved with respect to the acquisition duration. Our results show that, after a certain acquisition duration, the estimations of all functional networks reach their best and are stabilized. Since, for clinical application, the acquisition duration should be the shortest possible, we suggest an acquisition duration of 14 min, i.e., 240 volumes with our sequence parameters, as it covers the functional networks estimation stabilization.

SUBMITTER: Vallee C

PROVIDER: S-EPMC7406917 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Acquisition Duration in Resting-State Arterial Spin Labeling. How Long Is Enough?

Vallée Corentin C Maurel Pierre P Corouge Isabelle I Barillot Christian C

Frontiers in neuroscience 20200730

Resting-state Arterial Spin Labeling (rs-ASL) is a rather confidential method compared to resting-state BOLD. As ASL allows to quantify the cerebral blood flow, unlike BOLD, rs-ASL can lead to significant clinical subject-scaled applications. Despite directly impacting clinical practicability and functional networks estimation, there is no standard for rs-ASL regarding the acquisition duration. Our work here focuses on assessing the feasibility of ASL as an rs-fMRI method and on studying the eff ...[more]

PMID: 32848529

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Project description:BackgroundArterial spin labeling (ASL) perfusion-weighted imaging (PWI) by magnetic resonance imaging (MRI) has been shown to be useful for identifying asphyxiated newborns at risk of developing brain injury, whether or not therapeutic hypothermia was administered. However, this technique has been only rarely used in newborns until now, because of the challenges to obtain sufficient signal-to-noise ratio (SNR) and spatial resolution in newborns.ObjectiveTo compare two methods of ASL-PWI (i.e., single inversion-time pulsed arterial spin labeling [single TI PASL], and pseudo-continuous arterial spin labeling [pCASL]) to assess brain perfusion in asphyxiated newborns treated with therapeutic hypothermia and in healthy newborns.Design/methodsWe conducted a prospective cohort study of term asphyxiated newborns meeting the criteria for therapeutic hypothermia; four additional healthy term newborns were also included as controls. Each of the enrolled newborns was scanned at least once during the first month of life. Each MRI scan included conventional anatomical imaging, as well as PASL and pCASL PWI-MRI. Control and labeled images were registered separately to reduce the effect of motion artifacts. For each scan, the axial slice at the level of the basal ganglia was used for comparisons. Each scan was scored for its image quality. Quantification of whole-slice cerebral blood flow (CBF) was done afterwards using previously described formulas.ResultsA total number of 61 concomitant PASL and pCASL scans were obtained in nineteen asphyxiated newborns treated with therapeutic hypothermia and four healthy newborns. After discarding the scans with very poor image quality, 75% (46/61) remained for comparison between the two ASL methods. pCASL images presented a significantly superior image quality score compared to PASL images (p < 0.0001). Strong correlation was found between the CBF measured by PASL and pCASL (r = 0.61, p < 0.0001).ConclusionThis study demonstrates that both ASL methods are feasible to assess brain perfusion in healthy and sick newborns. However, pCASL might be a better choice over PASL in newborns, as pCASL perfusion maps had a superior image quality that allowed a more detailed identification of the different brain structures.

Dataset Information

Acquisition Duration in Resting-State Arterial Spin Labeling. How Long Is Enough?

Publications

Acquisition Duration in Resting-State Arterial Spin Labeling. How Long Is Enough?

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