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Selective prophylactic lateral node dissection improves the ipsilateral lateral node recurrence-free survival: A retrospective single-center cohort study.

ABSTRACT: Background:Some studies have shown that prophylactic lateral neck dissection (pLND) may be beneficial for patients with papillary thyroid carcinoma (PTC); however, none of the Western guidelines currently recommends this procedure. Since 2007, the decision to perform pLND at our institution has been made on a case-by-case basis with different risk factors in mind. In this study, we investigated the significance and indications of pLND in patients with PTC. Methods:We identified patients at stage N0 or N1a and M0 with PTC who underwent surgery from 2007 to 2017. We compared lateral compartment recurrence-free survival (RFS) and distant RFS between patients who did and did not undergo pLND (pLND and non-pLND groups). Results:pLND was performed in 494/3177 (15.5%) patients with PTC (tumor size [T] ?2 cm, cN0 or N1a, M0). Overall, no significant difference in lateral compartment RFS was detected between the pLND and non-pLND groups. On multivariate analysis, T ? 3 cm and positive extrathyroidal extension were independent predictors for recurrence to the lateral compartment. In the subset analysis of T ? 3 cm with positive extrathyroidal extension (n = 127), the lateral compartment RFS rate of the pLND group was significantly better (p < 0.01) than that of the non-pLND group (p < 0.01). In this subset, pLND reduced recurrence to the lateral compartment by 20.7% during the 5-year follow-up. However, pLND did not improve distant RFS. Conclusions:pLND significantly improved lateral node RFS in patients having PTC ?3 cm with significant extrathyroidal extension. For such patients, pLND at initial surgery may be considered to avoid second surgery.

SUBMITTER: Fujishima M

PROVIDER: S-EPMC7406979 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Selective prophylactic lateral node dissection improves the ipsilateral lateral node recurrence-free survival: A retrospective single-center cohort study.

Fujishima Makoto M Miyauchi Akira A Ito Yasuhiro Y Kudo Takumi T Kihara Minoru M Miya Akihiro A

Annals of medicine and surgery (2012) 20200728

<h4>Background</h4>Some studies have shown that prophylactic lateral neck dissection (pLND) may be beneficial for patients with papillary thyroid carcinoma (PTC); however, none of the Western guidelines currently recommends this procedure. Since 2007, the decision to perform pLND at our institution has been made on a case-by-case basis with different risk factors in mind. In this study, we investigated the significance and indications of pLND in patients with PTC.<h4>Methods</h4>We identified pa ...[more]

PMID: 32793337

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Project description:The most frequent recurrence site of papillary thyroid carcinoma (PTC) is the cervical lymph nodes. The introduction of an electric linear probe for use with ultrasonography in 1996 improved preoperative lateral neck evaluations. Before 2006, however, our hospital routinely performed prophylactic modified neck dissection (p-MND) for N0 or N1a PTCs >1 cm to prevent node recurrence. In 2006, we changed our policy and the indications for p-MND to PTCs >3 cm and/or with significant extrathyroid extension. Here, we retrospectively compared lymph node recurrence-free survival between PTCs with/without p-MND.We examined the cases of N0 or N1 and M0 PTC patients who underwent initial surgery in 1992-2012. To compare lymph node recurrence-free survival between patients who did/did not undergo p-MND, we divided these patients into three groups (excluding those whose surgery was in 2006): the 2045 patients whose surgery was performed in 1992-1996 (Group 1), the 2989 with surgery between 1997 (post-introduction of ultrasound electric linear probes) and 2005 (Group 2), and the 5332 operated on in 2007-2012 (Group 3).The p-MND performance rate of Group 3 (9%) was much lower than that of Group 1 (80%), but the lymph node recurrence-free survival of the former was significantly better, probably due to differences in clinical features and neck evaluations by ultrasound between the two groups. Our analysis of the patients aged <75 years with 1.1-4-cm PTCs in Groups 2 and 3 showed that p-MND did not improve lymph node recurrence-free survival. p-MND did significantly improve lymph node recurrence-free survival for the extrathyroid extension-positive 3.1-4-cm PTCs, but not for the other subsets.Abolishing routine p-MND for PTCs in 2006 did not decrease lymph node recurrence-free survival, probably due to improved ultrasound preoperative neck evaluations and clinical feature changes. Selective p-MND for high-risk cases improved lymph node recurrence-free survival.

Project description:BACKGROUND:The impact of lateral lymph node dissection (LLND) in locally advanced lower rectal cancer remains controversial. This study is to compare total mesorectal excision (TME) with or without LLND in lower rectal cancer cases of stage II/III. METHODS:The electronic databases were systematically searched that compared TME with or without LLND among patients with lower rectal cancer in clinical stage II/III. Subgroup analysis was performed considering neoadjuvant chemoradiotherapy (nCRT). The hazard ratios (HR), relative risk (RR), and weighted mean difference (WMD) were pooled. RESULTS:Twelve studies of 4458 patients of this meta-analysis demonstrate, LLND alone significantly reduced the local recurrence rate of patients who did not receive nCRT (RR 0.71, P = 0.004), while the difference was not significant when combined with nCRT (RR 0.70, P = 0.36). The analysis shows TME with LLND was associated with significantly longer operation time (WMD 90.73 min, P < 0.001), more intraoperative blood loss (WMD 303.20 mL, P < 0.001), and postoperative complications (RR = 1.35, P =0.02). Whereas urinary dysfunction (RR 1.44, P = 0.38), sexual dysfunction (RR 1.41, P = 0.17), and postoperative mortality (RR = 1.52, P = 0.70), were similar between these two groups. Statistically, no significant differences were observed in OS (HR 0.93, P = 0.62), DFS (HR 0.99, P = 0.96), total recurrence (RR 0.98, P = 0.83), lateral recurrence (RR 0.49, P = 0.14), or distal recurrence (RR 0.95, P = 0.78) between these two groups regardless of whether nCRT was performed or not. CONCLUSIONS:The study shows LLND alone decreases the local recurrence without using nCRT irrespective of the survival advantage in locally advanced lower rectal cancer. The benefit of controlling local recurrence by LLND alone makes us reconsider the usage of nCRT with LLND. TRIAL REGISTRATION:The protocol for this meta-analysis was registered prospectively with PROSPERO ( CRD42020135575 ) on 16 May 2019.

Dataset Information

Selective prophylactic lateral node dissection improves the ipsilateral lateral node recurrence-free survival: A retrospective single-center cohort study.

Publications

Selective prophylactic lateral node dissection improves the ipsilateral lateral node recurrence-free survival: A retrospective single-center cohort study.

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