Ontology highlight
ABSTRACT:
SUBMITTER: Nogueras-Ortiz CJ
PROVIDER: S-EPMC7407141 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nogueras-Ortiz Carlos J CJ Mahairaki Vasiliki V Delgado-Peraza Francheska F Das Debamitra D Avgerinos Konstantinos K Eren Erden E Hentschel Matthew M Goetzl Edward J EJ Mattson Mark P MP Kapogiannis Dimitrios D
Cells 20200704 7
We have previously shown that blood astrocytic-origin extracellular vesicles (AEVs) from Alzheimer's disease (AD) patients contain high complement levels. To test the hypothesis that circulating EVs from AD patients can induce complement-mediated neurotoxicity involving Membrane Attack Complex (MAC) formation, we assessed the effects of immunocaptured AEVs (using anti-GLAST antibody), in comparison with neuronal-origin (N)EVs (using anti-L1CAM antibody), and nonspecific CD81+ EVs (using anti-CD8 ...[more]