Ontology highlight
ABSTRACT:
SUBMITTER: Tolosa-Diaz A
PROVIDER: S-EPMC7407159 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Tolosa-Díaz Andrés A Almendro-Vedia Víctor G VG Natale Paolo P López-Montero Iván I
Biomolecules 20200721 7
Mitochondria are double-membrane organelles that continuously undergo fission and fusion. Outer mitochondrial membrane fusion is mediated by the membrane proteins mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2), carrying a GTP hydrolyzing domain (GTPase) and two coiled-coil repeats. The detailed mechanism on how the GTP hydrolysis allows Mfns to approach adjacent membranes into proximity and promote their fusion is currently under debate. Using model membranes built up as giant unilamellar vesicles (G ...[more]