Ontology highlight
ABSTRACT:
SUBMITTER: Escrig A
PROVIDER: S-EPMC7407279 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Escrig Anna A Molinero Amalia A Méndez Brenda B Giralt Mercedes M Comes Gemma G Sanchis Paula P Fernández-Gayol Olaya O Giménez-Llort Lydia L Becker-Pauly Christoph C Rose-John Stefan S Hidalgo Juan J
Cells 20200702 7
Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which may cause major health problems <i>per se</i>, are risk factors for AD, and cytokines such as interleukin-6 (IL-6) have a role in these conditions. IL-6 can signal either through a membrane receptor or by trans-signaling, which can be inhibited by the soluble form of the co-receptor gp130 (sgp130). We have addressed the possibility that blo ...[more]