Progressing Towards the Sustainable Development of Cream Formulations.

ABSTRACT: This work aims at providing the assumptions to assist the sustainable development of cream formulations. Specifically, it envisions to rationalize and predict the effect of formulation and process variability on a 1% hydrocortisone cream quality profile, interplaying microstructure properties with product performance and stability. This tripartite analysis was supported by a Quality by Design approach, considering a three-factor, three-level Box-Behnken design. Critical material attributes and process parameters were identified from a failure mode, effects, and criticality analysis. The impact of glycerol monostearate amount, isopropyl myristate amount, and homogenization rate on relevant quality attributes was estimated crosswise. The significant variability in product droplet size, visco

SUBMITTER: Simoes A 

PROVIDER: S-EPMC7407566 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature