Ontology highlight
ABSTRACT:
SUBMITTER: Uehata T
PROVIDER: S-EPMC7407594 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Uehata Takuya T Takeuchi Osamu O
Cells 20200716 7
RNA acts as an immunostimulatory molecule in the innate immune system to activate nucleic acid sensors. It functions as an intermediate, conveying genetic information to control inflammatory responses. A key mechanism for RNA sensing is discriminating self from non-self nucleic acids to initiate antiviral responses reliably, including the expression of type I interferon (IFN) and IFN-stimulated genes. Another important aspect of the RNA-mediated inflammatory response is posttranscriptional regul ...[more]