Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Gomez JA
PROVIDER: S-EPMC7407646 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Rodríguez-Gómez José A JA Kavanagh Edel E Engskog-Vlachos Pinelopi P Engskog Mikael K R MKR Herrera Antonio J AJ Espinosa-Oliva Ana M AM Joseph Bertrand B Hajji Nabil N Venero José L JL Burguillos Miguel A MA
Cells 20200717 7
The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though the research of microglia spans over a century, the last two decades have increased our understanding exponentially. Here, we discuss the phenotypic transformation from homeostatic microglia towards reactive microglia, initiated by specific ligand binding to pattern recognition receptors including toll-like receptor-4 (TLR4) or triggering receptors expre ...[more]