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The Distribution of Circulating Tumor Cells Is Different in Metastatic Lobular Compared to Ductal Carcinoma of the Breast-Long-Term Prognostic Significance.


ABSTRACT: BACKGROUND:Invasive lobular carcinoma (ILC) has distinguishing features when compared to invasive ductal carcinoma of no special type (NST). In this study, we explored the distributional and prognostic characteristics of circulating tumor cells (CTCs) in metastatic ILC and NST. MATERIALS AND METHODS:Patients were included in an observational trial (ClinicalTrials.gov NCT01322893) with ILC (n = 28) and NST (n = 111). CTC count (number/7.5 mL blood) was evaluated with serial sampling (CellSearch). The primary endpoint was progression-free survival (PFS). RESULTS:The CTC counts were higher in ILC (median 70) than in NST cases (median 2) at baseline (p < 0.001). The evidence for ?5 CTCs as a prognostic factor for PFS in ILC was weak, but stronger with higher cut-offs (CTC ? 20: hazard ratio (HR) 3.0, p = 0.01) (CTC ? 80: HR 3.6, p = 0.004). In NST, however, the prognostic effect of CTCs ?5 was strong. Decline in CTC count from baseline to three months was associated with improved prognosis in ILC and NST. CONCLUSIONS:The number of CTCs is higher in ILC than in NST, implying that a higher CTC cut-off could be considered for ILC when applying the CellSearch technique.

SUBMITTER: Narbe U 

PROVIDER: S-EPMC7407940 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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The Distribution of Circulating Tumor Cells Is Different in Metastatic Lobular Compared to Ductal Carcinoma of the Breast-Long-Term Prognostic Significance.

Narbe Ulrik U   Bendahl Pär-Ola PO   Aaltonen Kristina K   Fernö Mårten M   Forsare Carina C   Jørgensen Charlotte Levin Tykjær CLT   Larsson Anna-Maria AM   Rydén Lisa L  

Cells 20200717 7


<h4>Background</h4>Invasive lobular carcinoma (ILC) has distinguishing features when compared to invasive ductal carcinoma of no special type (NST). In this study, we explored the distributional and prognostic characteristics of circulating tumor cells (CTCs) in metastatic ILC and NST.<h4>Materials and methods</h4>Patients were included in an observational trial (ClinicalTrials.gov NCT01322893) with ILC (<i>n</i> = 28) and NST (<i>n</i> = 111). CTC count (number/7.5 mL blood) was evaluated with  ...[more]

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