Ontology highlight
ABSTRACT:
SUBMITTER: Zhang D
PROVIDER: S-EPMC7407961 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhang Dangquan D Kanakkanthara Arun A
Cancers 20200629 7
Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. ...[more]