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Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex.


ABSTRACT: The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interaction with nucleosomal substrates, revealing the molecular function of individual subunits as well as the potential impact of cancer-associated mutations on the remodeling function. Here we review the structural conservation between yeast SWI/SNF and BAF and examine the role of highly mutated subunits within the BAF complex.

SUBMITTER: Marcum RD 

PROVIDER: S-EPMC7408276 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Structural Insights into the Evolutionarily Conserved BAF Chromatin Remodeling Complex.

Marcum Ryan D RD   Reyes Alexis A AA   He Yuan Y  

Biology 20200630 7


The switch/sucrose nonfermentable (SWI/SNF) family of proteins acts to regulate chromatin accessibility and plays an essential role in multiple cellular processes. A high frequency of mutations has been found in SWI/SNF family subunits by exome sequencing in human cancer, and multiple studies support its role in tumor suppression. Recent structural studies of yeast SWI/SNF and its human homolog, BAF (BRG1/BRM associated factor), have provided a model for their complex assembly and their interact  ...[more]

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