Ontology highlight
ABSTRACT:
SUBMITTER: Brasil GV
PROVIDER: S-EPMC7408395 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Brasil Guilherme Visconde GV Silva Dos Santos Danúbia D Mendonça Elias Ataide EA Mesquita Fernanda Cristina Paccola FCP Kasai-Brunswick Tais Hanae TH Cunha Sandro Torrentes da STD Pimentel Cibele Ferreira CF Vasconcelos-Dos-Santos Andréia de A Mendez-Otero Rosália R Azevedo Filho Clério Francisco de CF Goldenberg Regina Coeli Dos Santos RCDS Campos de Carvalho Antonio Carlos AC
Cells 20200707 7
Chagas disease discovered more than a century ago remains an incurable disease. The objective of this work was to investigate the therapeutic potential of cardiomyocytes derived from mouse embryonic stem cells (CM-mESC) in a model of chronic Chagasic cardiomyopathy (CCC). Mouse embryonic stem cells (mESC) were characterized, transduced with luciferase, and submitted to cardiac differentiation. CM-mESC were labeled with superparamagnetic iron oxide particles. To induce CCC, mice were infected wit ...[more]