Ontology highlight
ABSTRACT:
SUBMITTER: Mokaya J
PROVIDER: S-EPMC7408481 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Mokaya Jolynne J Maponga Tongai G TG McNaughton Anna L AL Van Schalkwyk Marije M Hugo Susan S Singer Joshua B JB Sreenu Vattipally B VB Bonsall David D de Cesare Mariateresa M Andersson Monique M Gabriel Shiraaz S Taljaard Jantje J Barnes Eleanor E Preiser Wolfgang W Van Rensburg Christo C Matthews Philippa C PC
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20200708
<h4>Introduction</h4>Tenofovir disoproxil fumarate (TDF) is widely recommended for treatment of chronic hepatitis B virus (HBV) infection because it is safe, affordable and has a high genetic barrier to resistance. TDF resistance associated mutations (RAMs) have been reported, but data are limited, particularly for Africa. We set out to identify potential RAMs in individuals with detectable HBV viraemia on TDF treatment.<h4>Methods</h4>We recruited adults with chronic HBV infection from Cape Tow ...[more]