NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy.
Ontology highlight
ABSTRACT:
SUBMITTER: Marmolejo-Martinez-Artesero S
PROVIDER: S-EPMC7408527 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
NeuroHeal Reduces Muscle Atrophy and Modulates Associated Autophagy.
Marmolejo-Martínez-Artesero Sara S Romeo-Guitart David D Mañas-García Laura L Barreiro Esther E Casas Caty C
Cells 20200628 7
Muscle wasting is an unmet medical need which leads to a reduction of myofiber diameter and a negative impact on the functional performance of daily activities. We previously found that a new neuroprotective drug called NeuroHeal reduced muscle atrophy produced by transient denervation. Aiming to decipher whether NeuroHeal has a direct role in muscle biology, we used herein different models of muscle atrophy: one caused by chronic denervation, another caused by hindlimb immobilization, and lastl ...[more]
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