HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration.
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ABSTRACT:
SUBMITTER: Sugita S
PROVIDER: S-EPMC7408794 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration.
Sugita Sunao S Mandai Michiko M Hirami Yasuhiko Y Takagi Seiji S Maeda Tadao T Fujihara Masashi M Matsuzaki Mitsuhiro M Yamamoto Midori M Iseki Kyoko K Hayashi Naoko N Hono Ayumi A Fujino Shoko S Koide Naoshi N Sakai Noriko N Shibata Yumiko Y Terada Motoki M Nishida Mitsuhiro M Dohi Hiromi H Nomura Masaki M Amano Naoki N Sakaguchi Hirokazu H Hara Chikako C Maruyama Kazuichi K Daimon Takashi T Igeta Masataka M Oda Toshihiko T Shirono Utako U Tozaki Misato M Totani Kota K Sugiyama Satoshi S Nishida Kohji K Kurimoto Yasuo Y Takahashi Masayo M
Journal of clinical medicine 20200713 7
Immune attacks are key issues for cell transplantation. To assess the safety and the immune reactions after iPS cells-derived retinal pigment epithelium (iPS-RPE) transplantation, we transplanted HLA homozygote iPS-RPE cells established at an iPS bank in HLA-matched patients with exudative age-related macular degeneration. In addition, local steroids without immunosuppressive medications were administered. We monitored immune rejections by routine ocular examinations as well as by lymphocytes-gr ...[more]
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