Ontology highlight
ABSTRACT:
SUBMITTER: Ambur Sankaranarayanan R
PROVIDER: S-EPMC7408801 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ambur Sankaranarayanan Ramya R Kossatz Susanne S Weber Wolfgang W Beheshti Mohsen M Morgenroth Agnieszka A Mottaghy Felix M FM
Journal of clinical medicine 20200706 7
The central paradigm of novel therapeutic approaches in cancer therapy is identifying and targeting molecular biomarkers. One such target is the nuclear DNA repair enzyme Poly-(ADP ribose) polymerase 1 (PARP1). Sensitivity to PARP inhibition in certain cancers such as gBRCA<sup>mut</sup> breast and ovarian cancers has led to its exploitation as a target. The overexpression of PARP1 in several types of cancer further evoked interest in its use as an imaging target. While PARP1-targeted inhibitors ...[more]