Unknown

Dataset Information

0

The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.


ABSTRACT: To evaluate the performance of the 21-gene recurrence score (RS) assay in predicting chemotherapy benefit in the Surveillance, Epidemiology, and End Results population, we aimed to assess breast cancer-specific mortality (BCSM) by chemotherapy use within each of the RS categories. Data on breast cancer (BC) cases diagnosed between 2004 and 2015 with available RS results were released. Our analysis included patients with hormone receptor-positive, node-negative early-stage BC (n = 89,402), and three RS groups were defined; RS < 11, low; RS 11-25, intermediate; RS > 25, high. A propensity score matched-analysis was performed to assess and compare BCSM. Chemotherapy was significantly associated with a reduced risk of BC death among patients in the high RS group (hazard ratio = 0.782; 95% CI, 0.618-0.990; p = 0.041). However, in the low and intermediate RS groups, there were no significant differences in BCSM between patients who received chemotherapy and those who did not. Among those with RS 11-25, chemotherapy benefit varied with tumor size (p = 0.001). Our findings provide real-world evidence that the 21-gene RS assay is predictive of chemotherapy benefit among patients in clinical practice. More refined risk estimates would be needed for patients with an intermediate RS.

SUBMITTER: Choi IS 

PROVIDER: S-EPMC7408834 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

The 21-Gene Recurrence Score Assay and Prediction of Chemotherapy Benefit: A Propensity Score-Matched Analysis of the SEER Database.

Choi In Sil IS   Jung Jiwoong J   Kim Byoung Hyuck BH   Oh Sohee S   Kim Jongjin J   Park Jin Hyun JH   Park Jeong Hwan JH   Hwang Ki-Tae KT  

Cancers 20200708 7


<h4>Background</h4>To evaluate the performance of the 21-gene recurrence score (RS) assay in predicting chemotherapy benefit in the Surveillance, Epidemiology, and End Results population, we aimed to assess breast cancer-specific mortality (BCSM) by chemotherapy use within each of the RS categories.<h4>Methods</h4>Data on breast cancer (BC) cases diagnosed between 2004 and 2015 with available RS results were released. Our analysis included patients with hormone receptor-positive, node-negative e  ...[more]

Similar Datasets

| S-EPMC9385768 | biostudies-literature
| S-EPMC9640680 | biostudies-literature
| S-EPMC11003629 | biostudies-literature
| S-EPMC6757394 | biostudies-literature
| S-EPMC7877359 | biostudies-literature
| S-EPMC10063892 | biostudies-literature
| S-EPMC6198236 | biostudies-literature
| S-EPMC5881012 | biostudies-literature
| S-EPMC8275534 | biostudies-literature
| S-EPMC5648884 | biostudies-literature