Ontology highlight
ABSTRACT:
SUBMITTER: Santopolo G
PROVIDER: S-EPMC7409130 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Santopolo Giuseppe G Magnusson Jens P JP Lindvall Olle O Kokaia Zaal Z Frisén Jonas J
Cells 20200720 7
Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notc ...[more]