The Ubiquitin Proteasome System in Hematological Malignancies: New Insight into Its Functional Role and Therapeutic Options.
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ABSTRACT:
SUBMITTER: Di Costanzo A
PROVIDER: S-EPMC7409207 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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The Ubiquitin Proteasome System in Hematological Malignancies: New Insight into Its Functional Role and Therapeutic Options.
Di Costanzo Antonella A Del Gaudio Nunzio N Conte Lidio L Altucci Lucia L
Cancers 20200714 7
The ubiquitin proteasome system (UPS) is the main cellular degradation machinery designed for controlling turnover of critical proteins involved in cancer pathogenesis, including hematological malignancies. UPS plays a functional role in regulating turnover of key proteins involved in cell cycle arrest, apoptosis and terminal differentiation. When deregulated, it leads to several disorders, including cancer. Several studies indicate that, in some subtypes of human hematological neoplasms such as ...[more]
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