Ontology highlight
ABSTRACT:
SUBMITTER: Kervarrec T
PROVIDER: S-EPMC7409360 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kervarrec Thibault T Samimi Mahtab M Hesbacher Sonja S Berthon Patricia P Wobser Marion M Sallot Aurélie A Sarma Bhavishya B Schweinitzer Sophie S Gandon Théo T Destrieux Christophe C Pasqualin Côme C Guyétant Serge S Touzé Antoine A Houben Roland R Schrama David D
Cancers 20200721 7
Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV). It is still under discussion, in which cells viral integration and MCC development occurs. Recently, we demonstrated that a virus-positive MCC derived from a trichoblastoma, an epithelial neoplasia bearing Merkel cell (MC) differentiation potential. Accordingly, we hypothesized that MC progenitors may represent an origin of MCPyV-positive MCC. To sustain this hypothesis, phenotypic ...[more]