Retrospective study of the differential diagnosis between cryptogenic multifocal ulcerous stenosing enteritis and small bowel Crohn's disease.

ABSTRACT: BACKGROUND:Being a rare disease, cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is easily misdiagnosed as small bowel Crohn's disease (SBCD). AIMS:This study was aimed to compare clinical features of CMUSE to SBCD. METHODS:Fourteen patients with CMUSE and 61 patients with SBCD were retrospectively analyzed. RESULTS:Hematochezia was more frequent in CMUSE patients (10, 71.4% vs 23, 37.7%, P?=?0.022), while diarrhea was more common in SBCD patients (23, 37.7% vs 0, 0.0%, P?=?0.015). More patients with CMUSE developed intestinal stenosis than with SBCD (14, 100% vs 37, 60.7%, P?=?0.011). 30 (50.0%) SBCD patients and none CMUSE patients had an elevated erythrocyte sedimentation rate level (P?=?0.001). Extra-enteric findings found by computed tomography enterography were significantly more prevalent in SBCD patients than in CMUSE patients (25,71.4% vs 3,25%, P?=?0.013). Longitudinal ulcers found by endoscopy were more common in SBCD patients (16, 37.2% vs 0, 0.0%, P?=?0.041), while circumferential ulcers were more common in CMUSE patients (6, 54.6% vs 8, 18.6%, P?=?0.041). All ulcers observed in CMUSE patients were within mucosal and submucosal layers, but 8 (44.4%) SBCD patients had deep ulcers that reached beyond submucosal layers (P?=?0.003). Ulcers were located at strictures in 9 (90.0%) CMUSE patients but only in 1 (5.6%) SBCD patient (P?=?0.000). CONCLUSIONS:Gastrointestinal symptoms, erythrocyte sedimentation rate levels, radiologic, endoscopic and pathologic features help to distinguish CMUSE from SBCD.

SUBMITTER: Chen D 

PROVIDER: S-EPMC7409495 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature