Ontology highlight
ABSTRACT:
SUBMITTER: Inde Z
PROVIDER: S-EPMC7409774 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Cell reports 20200701 1
Lethal drugs can induce incomplete cell death in a population of cancer cells, a phenomenon referred to as fractional killing. Here, we show that high-throughput population-level time-lapse imaging can be used to quantify fractional killing in response to hundreds of different drug treatments in parallel. We find that stable intermediate levels of fractional killing are uncommon, with many drug treatments resulting in complete or near-complete eradication of all cells, if given enough time. The ...[more]