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Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?

ABSTRACT: SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys189-X-X-Cys192-X n -Cys224-X-Cys226) and a classic catalytic site (Cys111-His272-Asp286), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading to dysfunction of CoV-2-PLpro and thereby halting viral replication.

SUBMITTER: Maiti BK

PROVIDER: S-EPMC7409920 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Can Papain-like Protease Inhibitors Halt SARS-CoV-2 Replication?

Maiti Biplab K BK

ACS pharmacology & translational science 20200804 5

SARS-CoV-2 encoded papain-like protease (PLpro) harbors a labile Zn site (Cys189-X-X-Cys192-X n -Cys224-X-Cys226) and a classic catalytic site (Cys111-His272-Asp286), which play key roles for viral replication and hence represent promising drug targets. In this Viewpoint, both sulfur-based drugs and peptides-based inhibitors may block Cys residues in the catalytic and/or Zn site of CoV-2-PLpro, leading ...[more]

PMID: 33062954

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