Ontology highlight
ABSTRACT:
SUBMITTER: Laurence J
PROVIDER: S-EPMC7410014 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Clinical immunology (Orlando, Fla.) 20200806
Respiratory failure and acute kidney injury (AKI) are associated with high mortality in SARS-CoV-2-associated Coronavirus disease 2019 (COVID-19). These manifestations are linked to a hypercoaguable, pro-inflammatory state with persistent, systemic complement activation. Three critical COVID-19 patients recalcitrant to multiple interventions had skin biopsies documenting deposition of the terminal complement component C5b-9, the lectin complement pathway enzyme MASP2, and C4d in microvascular en ...[more]