Ontology highlight
ABSTRACT:
SUBMITTER: Such L
PROVIDER: S-EPMC7410049 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Such Lina L Zhao Fang F Liu Derek D Thier Beatrice B Le-Trilling Vu Thuy Khanh VTK Sucker Antje A Coch Christoph C Pieper Natalia N Howe Sebastian S Bhat Hilal H Kalkavan Halime H Ritter Cathrin C Brinkhaus Robin R Ugurel Selma S Köster Johannes J Seifert Ulrike U Dittmer Ulf U Schuler Martin M Lang Karl S KS Kufer Thomas A TA Hartmann Gunther G Becker Jürgen C JC Horn Susanne S Ferrone Soldano S Liu David D Van Allen Eliezer M EM Schadendorf Dirk D Griewank Klaus K Trilling Mirko M Paschen Annette A
The Journal of clinical investigation 20200801 8
Understanding tumor resistance to T cell immunotherapies is critical to improve patient outcomes. Our study revealed a role for transcriptional suppression of the tumor-intrinsic HLA class I (HLA-I) antigen processing and presentation machinery (APM) in therapy resistance. Low HLA-I APM mRNA levels in melanoma metastases before immune checkpoint blockade (ICB) correlated with nonresponsiveness to therapy and poor clinical outcome. Patient-derived melanoma cells with silenced HLA-I APM escaped re ...[more]