Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC7410082 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chen Tingjun T Lennon Vanda A VA Liu Yong U YU Bosco Dale B DB Li Yujiao Y Yi Min-Hee MH Zhu Jia J Wei Shihui S Wu Long-Jun LJ
The Journal of clinical investigation 20200801 8
Neuromyelitis optica (NMO) is a severe inflammatory autoimmune CNS disorder triggered by binding of an IgG autoantibody to the aquaporin 4 (AQP4) water channel on astrocytes. Activation of cytolytic complement has been implicated as the major effector of tissue destruction that secondarily involves myelin. We investigated early precytolytic events in the evolving pathophysiology of NMO in mice by continuously infusing IgG (NMO patient serum-derived or AQP4-specific mouse monoclonal), without exo ...[more]