Ontology highlight
ABSTRACT:
SUBMITTER: DeFrees K
PROVIDER: S-EPMC7410147 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Organic chemistry frontiers : an international journal of organic chemistry 20190515 11
Compared to aryl-aryl π-stacking interactions, the analogous stacking of heteroarenes on amide π systems is less well understood and vastly underutilized in structure-based drug design. Recent theoretical studies have delineated the important geometric coordinates of the interaction, some of which have been confirmed with synthetic model systems based on Rebek imides. Unfortunately, a broadly useful and tractable protein-ligand model system of this interaction has remained elusive. Here we emplo ...[more]