Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys.

ABSTRACT: OBJECTIVE:In adult female rodents, ovarian estradiol (E2) regulates body weight, adiposity, energy balance, physical activity, glucose-insulin homeodynamics, and lipid metabolism, while protecting against diet-induced obesity. The same E2 actions are presumed to occur in primates, but confirmatory studies have been lacking. METHODS:We investigated the consequences of ovariectomy (OVX) and E2 replacement in female marmoset monkeys on major metabolic and morphometric endpoints. Sexual behavior and uterine diameters were assessed as positive controls for E2 treatment efficacy. Metabolic parameters were measured 1?mo prior to OVX, and 3 and 6?mo thereafter. During OVX, animals received empty or E2-containing silastic s.c. implants. To test the interaction between E2 and diet, both treatment groups were assigned to either a higher fat diet (HFD) or a low-fat diet (LFD). RESULTS:As anticipated, OVX animals exhibited diminished frequency (p?=?0.04) of sexually receptive behavior and increased rejection behavior (p?=?0.04) toward their male partners compared with E2-treated OVX females. OVX also decreased (p?=?0.01) uterine diameter. There were no treatment effects on total caloric intake. There were no significant effects of OVX, E2 treatment, or diet on body weight, body composition, energy expenditure, physical activity, fasting glucose, or glucose tolerance. Regardless of E2 treatment, serum triglycerides were higher (p?=?0.05) in HFD than LFD females. Postmortem qPCR analysis of hypothalamic tissues revealed higher mRNA expression (p?

SUBMITTER: Kraynak M 

PROVIDER: S-EPMC7410230 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature