Regularized-Ncut: Robust and homogeneous functional parcellation of neonate and adult brain networks.

ABSTRACT: Brain network parcellation based on resting-state functional MRI (rs-fMRI) is affected by noise, resulting in spurious small patches and decreased functional homogeneity within each network. Obtaining robust and homogeneous parcellation of neonate brain is more difficult, because neonate rs-fMRI is associated with relatively higher level of noise and no prior knowledge from a functional neonate atlas is available as spatial constraints. To meet these challenges, we developed a novel data-driven Regularized Normalized-cut (RNcut) method. RNcut is formulated by adding two regularization terms, a smoothing term using Markov random fields and a small-patch removal term, to conventional normalized-cut (Ncut) method. The RNcut and competing methods were tested with simulated datasets with known ground truth and then applied to both adult and neonate rs-fMRI datasets. Based on the parcellated networks generated by RNcut, intra-network connectivity was quantified. The test results from simulated datasets demonstrated that the RNcut method is more robust (p?

SUBMITTER: Peng Q 

PROVIDER: S-EPMC7410361 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature