Dataset Information

Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice.

ABSTRACT: Cerebellar malfunction can lead to sleep disturbance such as excessive daytime sleepiness, suggesting that the cerebellum may be involved in regulating sleep and/or wakefulness. However, understanding the features of cerebellar regulation in sleep and wakefulness states requires a detailed characterization of neuronal activity within this area. By performing multiple-unit recordings in mice, we showed that Purkinje cells (PCs) in the cerebellar cortex exhibited increased firing activity prior to the transition from sleep to wakefulness. Notably, the increased PC activity resulted from the inputs of low-frequency non-PC units in the cerebellar cortex. Moreover, the increased PC activity was accompanied by decreased activity in neurons of the deep cerebellar nuclei at the non-rapid eye-movement sleep-wakefulness transition. Our results provide in vivo electrophysiological evidence that the cerebellum has the potential to actively regulate the sleep-wakefulness transition.

SUBMITTER: Zhang LB

PROVIDER: S-EPMC7410897 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice.

Zhang Li-Bin LB Zhang Jie J Sun Meng-Jia MJ Chen Hao H Yan Jie J Luo Fen-Lan FL Yao Zhong-Xiang ZX Wu Ya-Min YM Hu Bo B

Neuroscience bulletin 20200519 8

Cerebellar malfunction can lead to sleep disturbance such as excessive daytime sleepiness, suggesting that the cerebellum may be involved in regulating sleep and/or wakefulness. However, understanding the features of cerebellar regulation in sleep and wakefulness states requires a detailed characterization of neuronal activity within this area. By performing multiple-unit recordings in mice, we showed that Purkinje cells (PCs) in the cerebellar cortex exhibited increased firing activity prior to ...[more]

PMID: 32430873

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Project description:BackgroundMotor activity fluctuations in healthy adults exhibit fractal patterns characterized by consistent temporal correlations across wide-ranging time scales. However, these patterns are disrupted by aging and psychiatric conditions. This study aims to investigate how fractal patterns vary across the sleep-wake cycle, differ based on individuals' recency of depression diagnosis, and change before and after a depressive episode.MethodsUsing actigraphy from two cohorts (n = 378), we examined fractal motor activity patterns both between individuals without depression and with varying recencies of depression and within individuals before and after depressive symptom recurrence. To evaluate fractal patterns, we quantified temporal correlations in motor activity fluctuations across different time scales using a scaling exponent, α. Linear mixed models were utilized to assess the influence of the sleep-wake cycle, (recency of) depression, and their interaction on α.ResultsFractal activity patterns in all individuals varied across the sleep-wake cycle, showing stronger temporal correlations during wakefulness (larger α = 1.035 ± 0.003) and more random activity fluctuations during sleep (smaller α = 0.784 ± 0.004, p < 0.001). This sleep-wake difference was reduced in recently depressed individuals (1-6 months), leading to larger α during sleep (0.836 ± 0.017), compared to currently depressed (0.781 ± 0.018, p = 0.006), remitted (0.776 ± 0.014, p < 0.001), and never-depressed individuals (0.773 ± 0.016, p < 0.001). Moreover, remitted individuals who experienced depressive symptom recurrence during antidepressant tapering exhibited a larger α during sleep after the symptom onset as compared to before (after: α = 0.703 ± 0.022; before: α = 0.680 ± 0.022; p < 0.001).ConclusionsThese findings suggest a link between fractal motor activity patterns during sleep and depressive symptom recurrence in remitted individuals and those with recent depression.

Dataset Information

Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice.

Publications

Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice.

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